Article
Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for molecular screening.
Clinical chemistry and laboratory medicine - 1 Jan 2006
Andreassi Maria Grazia, Botto Nicoletta, Maffei Silvia
Abstract excerpt
Venous thromboembolism is a well-known complication of oral contraception and hormonal replacement therapy. Inherited thrombophilia is viewed as an important determinant in modulating the effects of estrogens on thrombotic risk. An increasing number of kits for thrombophilic mutations [factor V Leiden, G20210A prothrombin and methylenetetrahydrofolate reductase (MTHFR) C677T genes] are becoming commercially...
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