Article
Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer.
Cancer letters - 8 Feb 2007
Costa Sandra, Pinto Daniela, Pereira Deolinda, Vasconcelos André, Afonso-Lopes Carlos, Osório Teresa, Lopes Carlos, Medeiros Rui
Abstract excerpt
The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case-control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR=2.46 95% CI 1.20-5.06;...
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