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Article

Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis

5 Jun 2020

Abstract excerpt

Abstract Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7+/− and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7+/− and wild-type time-pregnant mice were exposed to vehicle or 0.2 mg/kg CAR from E12 to E19. Levels of CAR, CAR...

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PMID: 32504050
DOI: 10.1038/s41380-020-0801-x

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