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Article

A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis.

The Journal of experimental medicine - 15 May 2006

Trapp Sascha, Parcells Mark S, Kamil Jeremy P, Schumacher Daniel, Tischer B Karsten, Kumar Pankaj M, Nair Venugopal K, Osterrieder Nikolaus

Abstract excerpt

Telomerase is a ribonucleoprotein complex consisting of two essential core components: a reverse transcriptase and an RNA subunit (telomerase RNA [TR]). Dysregulation of telomerase has been associated with cell immortalization and oncogenesis. Marek's disease herpesvirus (MDV) induces a malignant T cell lymphoma in chickens and harbors in its genome two identical copies of a viral TR (vTR) with 88% sequence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16651385
DOI: 10.1084/jem.20052240
PMCID: PMC2121211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis.PMID 16651385Read ↗

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