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Article

Structural basis of carbohydrate transfer activity by human UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase (pp-GalNAc-T10).

Journal of molecular biology - 9 Jun 2006

Kubota Tomomi, Shiba Tomoo, Sugioka Shigemi, Furukawa Sanae, Sawaki Hiromichi, Kato Ryuich, Wakatsuki Soichi, Narimatsu Hisashi

Abstract excerpt

Mucin-type O-glycans are important carbohydrate chains involved in differentiation and malignant transformation. Biosynthesis of the O-glycan is initiated by the transfer of N-acetylgalactosamine (GalNAc) which is catalyzed by UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-Ts). Here we present crystal structures of the pp-GalNAc-T10 isozyme, which has specificity for glycosylated...

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Identifiers

PMID: 16650853
DOI: 10.1016/j.jmb.2006.03.061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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