Article
Hepatitis B virus genotypes and G1896A precore mutation in 486 Spanish patients with acute and chronic HBV infection.
Journal of viral hepatitis - 1 May 2006
Rodriguez-Frias F, Jardi R, Buti M, Schaper M, Hermosilla E, Valdes A, Allende H, Martell M, Esteban R, Guardia J
Abstract excerpt
This study aims to determine the prevalence of hepatitis B virus (HBV) genotypes (A-F) and their association with the G1896A precore mutation in 486 patients positive for HBV surface antigen. Genotypes were determined by RFLP and precore mutation by real-time PCR. Genotypes D (48.1%) and A (39.5%) were the most common, followed by F (4.1%) and B, C and E (<1%). The A to D ratio (A:D) was 1.4 in HBeAg+ chronic...
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