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Article

Polymorphisms in manganese superoxide dismutase and catalase genes: functional study in Hong Kong Chinese asthma patients.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Apr 2006

Mak J C W, Leung H C M, Ho S P, Ko F W S, Cheung A H K, Ip M S M, Chan-Yeung M M W

Abstract excerpt

BACKGROUND: Reactive oxygen species may contribute to the pathogenesis of asthma. Functional genetic polymorphisms of antioxidant enzymes, superoxide dismutase (SOD) and catalase are good candidates for asthma susceptibility. OBJECTIVE: To investigate the association of the manganese-containing form of SOD (MnSOD) gene at amino acid position 16 (Val16Ala) and catalase gene in the promoter at A-21T and C-262T...

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PMID: 16630148
DOI: 10.1111/j.1365-2222.2006.02458.x

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