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Scalable production of adeno‐associated virus type 2 vectors via suspension transfection

18 Apr 2006

Abstract excerpt

Vectors derived from adeno-associated virus type 2 (AAV2) are promising gene delivery vehicles, but it is still challenging to get the large number of recombinant adeno-associated virus (rAAV) particles required for large animal and clinical studies. Current transfection technology requires adherent cultures of HEK 293 cells that can only be expanded by preparing multiple culture plates. A single large-scale...

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PMID: 16622883
DOI: 10.1002/bit.20776

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