Article
Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults.
The Journal of infectious diseases - 15 May 2006
Kelly Paul, Bajaj-Elliott Mona, Katubulushi Max, Zulu Isaac, Poulsom Richard, Feldman Roger A, Bevins Charles L, Dhaliwal Winnie
Abstract excerpt
BACKGROUND: Human defensin (HD) 5 and HD6, both Paneth cell alpha-defensins, contribute to the antimicrobial barrier against intestinal infection. We have previously demonstrated that levels of both HD5 and HD6 mRNA were reduced in adults living in urban Zambia, compared with those in adults living in London. The aim of the present study was to determine, during 2 years of follow-up, whether alpha-defensin...
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