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Article

Analysis of LMP1 variants of EBV in Southern Thailand: evidence for strain-associated T-cell tropism and pathogenicity.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jun 2006

Saechan Vannarat, Mori Atsumi, Mitarnun Winyou, Settheetham-Ishida Wannapa, Ishida Takafumi

Abstract excerpt

BACKGROUND: The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) has sequence heterogeneity. Some of the variants are associated with altered tumorigenic activity and show geographically specific localization. In Thailand, the EBV genome is frequently detected in circulating T cells of T-cell diseases. OBJECTIVE: To determine the role of EBV LMP1 variation in the genesis of T-cell diseases, we focused...

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PMID: 16616610
DOI: 10.1016/j.jcv.2006.01.018

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SEA

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