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Article

Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2006

Dykxhoorn Derek M, Schlehuber Lisa D, London Irving M, Lieberman Judy

Abstract excerpt

A single nucleotide polymorphism (SNP) in the sickle beta-globin gene (beta(S)) leads to sickle cell anemia. Sickling increases sharply with deoxy sickle Hb concentration and decreases with increasing fetal gamma-globin concentration. Measures that decrease sickle Hb concentration should have an antisickling effect. RNA interference (RNAi) uses small interfering (si)RNAs for sequence-specific gene silencing. A...

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Identifiers

PMID: 16585504
DOI: 10.1073/pnas.0601309103
PMCID: PMC1458679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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