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Article

Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.

Molecular pharmacology - 1 Aug 2015

Teo Theodosia, Lam Frankie, Yu Mingfeng, Yang Yuchao, Basnet Sunita K C, Albrecht Hugo, Sykes Matthew J, Wang Shudong

Abstract excerpt

The Ras/Raf/MAPK and PI3K/Akt/mTOR pathways are key signaling cascades involved in the regulation of cell proliferation and survival, and have been implicated in the pathogenesis of several types of cancers, including acute myeloid leukemia (AML). The oncogenic activity of eIF4E driven by the Mnk kinases is a convergent determinant of the two cascades, suggesting that targeting the Mnk/eIF4E axis may provide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

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Source

Identifiers

PMID: 26044548
DOI: 10.1124/mol.115.098012

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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