Article
Role of HLA-B51 and HLA-B52 in susceptibility to pulmonary tuberculosis.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2006
Vijaya Lakshmi V, Rakh Shilpa S, Anu Radha B, Hari Sai Priya V, Pantula Vinod, Jasti Susmita, Suman Latha G, Murthy K J R
Abstract excerpt
MHC class I-restricted CD8+ T cells are important for the generation of protective immune responses in MTB infection. CD8+ CTL (cytotoxic T-lymphocyte)-derived IFN-g may be especially important both for cells lacking MHC class II molecules, e.g. in the lung and for macrophages where mycobacteria can evade recognition during chronic infection by sequestering their antigens away from sensitized CD4+ T cells. This...
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