Article
JAK2(V617F) and leukemic transformation in myelofibrosis with myeloid metaplasia.
Leukemia research - 1 Nov 2006
Mesa Ruben A, Powell Heather, Lasho Terra, Dewald Gordon, McClure Rebecca, Tefferi Ayalew
Abstract excerpt
Amongst 42 consecutive patients with leukemic transformation (LT) from myelofibrosis with myeloid metaplasia (MMM) 72% carried the JAK2(V617F) mutation. The mutation was observed at expected frequencies in all subtypes of MMM and acute myeloid leukemia. Although the patients with the mutation were younger and had a shorter interval to LT there was no difference in survival. Additionally, both the lack of mutation...
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