Article
An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies.
Acta neuropathologica - 1 Apr 2006
de Silva Rohan, Lashley Tammaryn, Strand Catherine, Shiarli Anna-Maria, Shi Jing, Tian Jinzhou, Bailey Kathryn L, Davies Peter, Bigio Eileen H, Arima Kunimasa, Iseki Eizo, Murayama Shigeo, Kretzschmar Hans, Neumann Manuela, Lippa Carol, Halliday Glenda, MacKenzie James, Ravid Rivka, Dickson Dennis, Wszolek Zbigniew, Iwatsubo Takeshi, Pickering-Brown Stuart M, Holton Janice, Lees Andrew, Revesz Tamas, Mann David M A
Abstract excerpt
The pathological distinctions between the various clinical and pathological manifestations of frontotemporal lobar degeneration (FTLD) remain unclear. Using monoclonal antibodies specific for 3- and 4-repeat isoforms of the microtubule associated protein, tau (3R- and 4R-tau), we have performed an immunohistochemical study of the tau pathology present in 14 cases of sporadic forms of FTLD, 12 cases with Pick...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.