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Article

The Treponema denticola surface protease dentilisin degrades interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha.

Infection and immunity - 1 Apr 2006

Miyamoto Meguru, Ishihara Kazuyuki, Okuda Katsuji

Abstract excerpt

Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.

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Identifiers

PMID: 16552080
DOI: 10.1128/IAI.74.4.2462-2467.2006
PMCID: PMC1418930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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