Article

<i>Treponema denticola</i> dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells

2021-01-18

Abstract excerpt

<h4>ABSTRACT</h4> Periodontal disease is driven by dysbiosis of the oral microbiome, resulting in over-representation of species that induce the release of pro-inflammatory cytokines, chemokines, and tissue-remodeling matrix metalloproteinases (MMPs) in the periodontium. These chronic tissue-destructive inflammatory responses result in gradual loss of tooth-supporting alveolar bone. The oral spirochete Treponema...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8c26814-8b62-56af-83d1-e37a80820b85
DOI: 10.1101/2021.01.18.427101

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Treponema denticola</i> dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cellsDOI 10.1101/2021.01.18.427101Read

MMP-12 and Periodontitis: Unraveling the Molecular Pathways of Periodontal Tissue DestructionSemantic proximity Read

Treponema denticolaincreases MMP-2 expression and activation in the periodontium via reversible DNA and histone modificationsSemantic proximity Read

Investigating the Role of Necroptosis in the Immunological Microenvironment of PeriodontitisSemantic proximity Read

Treponema denticola major surface protein (Msp): a key player in periodontal pathogenicity and immune evasionSemantic proximity Read

Oral Spirochete <em>Treponema denticola </em>Intraoral Infection Reveals Unique miR-133a, miR-486, miR-126-3p, miR-126-5p miRNA Expression Kinetics during PeriodontitisSemantic proximity Read

Characterization of the Treponema denticola Virulence Factor Dentilisin.Semantic proximity Read

Salivary Features of Periodontitis and Gingivitis in Type 2 Diabetes MellitusSemantic proximity Read

Polymicrobial periodontal disease triggers a wide radius of effect and unique viromeSemantic proximity Read

Localization and pathogenic role of the cysteine protease dentipain in Treponema denticolaSemantic proximity Read

Importance of Virulence Factors for the Persistence of Oral Bacteria in the Inflamed Gingival Crevice and in the Pathogenesis of Periodontal DiseaseSemantic proximity Read

Periodontitis Primes the Oral Microenvironment for PS-Dependent Non-Canonical Entry Pathways Linked to SARS-CoV-2 SusceptibilitySemantic proximity Read

Approaches to Understanding Mechanisms of Dentilisin Protease Complex Expression in Treponema denticolaSemantic proximity Read