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Article

Irinotecan Inactivation Is Modulated by Epigenetic Silencing of<i>UGT1A1</i>in Colon Cancer

15 Mar 2006

Abstract excerpt

PURPOSE: Irinotecan is used in the first-line treatment of metastatic colorectal cancer. The UGT1A1-metabolizing enzyme, expressed in liver and colon, is primarily involved in the inactivation of its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Herein, we explored the role of DNA methylation in the silencing of UGT1A1 gene expression in colon cancer and its influence on cellular SN-38 detoxification....

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Identifiers

PMID: 16551870
DOI: 10.1158/1078-0432.ccr-05-2130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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