Article
An intronic insertion in KPL2 results in aberrant splicing and causes the immotile short-tail sperm defect in the pig.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006
Sironen Anu, Thomsen Bo, Andersson Magnus, Ahola Virpi, Vilkki Johanna
Abstract excerpt
The immotile short-tail sperm defect is an autosomal recessive disease within the Finnish Yorkshire pig population. This disease specifically affects the axoneme structure of sperm flagella, whereas cilia in other tissues appear unaffected. Recently, the disease locus was mapped to a 3-cM region on porcine chromosome 16. To facilitate identification of candidate genes, we constructed a porcine-human comparative...
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