Article
Monitoring the antitumor response of naive and memory CD8 T cells in RAG1-/- mice by positron-emission tomography.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006
Su Helen, Chang Daisy S, Gambhir Sanjiv S, Braun Jonathan
Abstract excerpt
Therapeutic antitumor immunity depends on a highly migratory CTL population capable of activation and trafficking between lymphoid and tumor-bearing microanatomic sites. We recently adapted positron-emission tomography gene expression imaging for noninvasive, longitudinal localization and quantitation of antitumor T lymphocyte migration in vivo. In this study, we apply this system to enumerate the temporal...
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