Article
CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006
Hong Jian, Zang Ying C Q, Nie Hong, Zhang Jingwu Z
Abstract excerpt
Immunization with irradiated autologous T cells (T cell vaccination) is shown to induce regulatory T cell responses that are poorly understood. In this study, CD4(+) regulatory T cell lines were generated from patients with multiple sclerosis that received immunization with irradiated autologous myelin basic protein-reactive T cells. The resulting CD4(+) regulatory T cell lines had marked inhibition on autologous...
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