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Article

Porin-mediated antibiotic resistance in Neisseria gonorrhoeae: ion, solute, and antibiotic permeation through PIB proteins with penB mutations.

Journal of bacteriology - 1 Apr 2006

Olesky Melanie, Zhao Shuqing, Rosenberg Robert L, Nicholas Robert A

Abstract excerpt

Neisseria gonorrhoeae has two porins, PIA and PIB, whose genes (porA and porB, respectively) are alleles of a single por locus. We recently demonstrated that penB mutations at positions 120 and 121 in PIB, which are presumed to reside in loop 3 that forms the pore constriction zone, confer intermediate-level resistance to penicillin and tetracycline (M. Olesky, M. Hobbs, and R. A. Nicholas, Antimicrob. Agents...

Topics

Anti-Bacterial Agents
Carbohydrate Metabolism
Drug Resistance, Bacterial
Gene Expression Regulation, Bacterial
Mutation
Neisseria gonorrhoeae
Porins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 16547016
DOI: 10.1128/JB.188.7.2300-2308.2006
PMCID: PMC1428387

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Porin-mediated antibiotic resistance in Neisseria gonorrhoeae: ion, solute, and antibiotic permeation through PIB proteins with penB mutations.PMID 16547016Read ↗

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