Article
Generation and characterization of functional cardiomyocytes from rhesus monkey embryonic stem cells.
Stem cells (Dayton, Ohio) - 1 Jun 2006
Schwanke Kristin, Wunderlich Stephanie, Reppel Michael, Winkler Monica E, Matzkies Matthias, Groos Stephanie, Itskovitz-Eldor Joseph, Simon André R, Hescheler Jürgen, Haverich Axel, Martin Ulrich
Abstract excerpt
Embryonic stem cells (ESCs) from mice and humans (hESCs) have been shown to be able to efficiently differentiate toward cardiomyocytes (CMs). Because murine ESCs and hESCs do not allow for establishment of pre-clinical allogeneic transplantation models, the aim of our study was to generate functional CMs from rhesus monkey ESCs (rESCs). Although formation of ectodermal and neuronal/glial cells appears to be the...
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