Article
Phenotypic variation in bacteria: the role of feedback regulation.
Nature reviews. Microbiology - 1 Apr 2006
Smits Wiep Klaas, Kuipers Oscar P, Veening Jan-Willem
Abstract excerpt
To survive in rapidly changing environmental conditions, bacteria have evolved a diverse set of regulatory pathways that govern various adaptive responses. Recent research has reinforced the notion that bacteria use feedback-based circuitry to generate population heterogeneity in natural situations. Using artificial gene networks, it has been shown that a relatively simple 'wiring' of a bacterial genetic system...
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