Article
Defining aggressive prostate cancer using a 12-gene model.
Neoplasia (New York, N.Y.) - 1 Jan 2006
Bismar Tarek A, Demichelis Francesca, Riva Alberto, Kim Robert, Varambally Sooryanarayana, He Le, Kutok Jeff, Aster Jonathan C, Tang Jeffery, Kuefer Rainer, Hofer Matthias D, Febbo Phillip G, Chinnaiyan Arul M, Rubin Mark A
Abstract excerpt
The critical clinical question in prostate cancer research is: How do we develop means of distinguishing aggressive disease from indolent disease? Using a combination of proteomic and expression array data, we identified a set of 36 genes with concordant dysregulation of protein products that could be evaluated in situ by quantitative immunohistochemistry. Another five prostate cancer biomarkers were included...
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