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Article

An analysis of unclassified missense substitutions in human BRCA1.

Familial cancer - 1 Jan 2006

Tavtigian Sean V, Samollow Paul B, de Silva Deepika, Thomas Alun

Abstract excerpt

Classification of rare sequence variants observed during mutation screening of susceptibility genes in high-risk individuals presents an interesting and medically important challenge. A recently described method for analysis of unclassified variants in BRCA1 and BRCA2 provides an extensible framework within which several different types of analytic data can be integrated. Among the methods already integrated in...

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Share to BRCA1 Protein
Share to BRCA2 Protein
Share to Confidence Intervals

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Mutation, Missense

Share to Neoplastic Syndromes, Hereditary

Share to Odds Ratio

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 16528611
DOI: 10.1007/s10689-005-2578-0

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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