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Article

Intergeneration CAG expansion and contraction in a Chinese HD family.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2006

Tang Yanping, Wang Ying, Yang Ping, Liu Yuan, Wang Bo, Podolsky Robert, McIndoe Richard, Wang Cong-Yi

Abstract excerpt

The prevalence of juvenile-onset Huntington's disease (HD) is about ten times lower than adult HD. Here we report a Chinese HD family showing both intergeneration CAG expansion and contraction. The expansion resulted from a paternal transmission which leads to juvenile-onset HD for a 17-year-old Chinese boy (III-5). More interestingly, a contraction was noticed in a maternal transmission (III-3), which changed...

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PMID: 16526033
DOI: 10.1002/ajmg.b.30261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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