Article
Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2006
Iacopetta B, Russo A, Bazan V, Dardanoni G, Gebbia N, Soussi T, Kerr D, Elsaleh H, Soong R, Kandioler D, Janschek E, Kappel S, Lung M, Leung C-S S, Ko J M, Yuen S, Ho J, Leung S Y, Crapez E, Duffour J, Ychou M, Leahy D T, O'Donoghue D P, Agnese V, Cascio S, Di Fede G, Chieco-Bianchi L, Bertorelle R, Belluco C, Giaretti W, Castagnola P, Ricevuto E, Ficorella C, Bosari S, Arizzi C D, Miyaki M, Onda M, Kampman E, Diergaarde B, Royds J, Lothe R A, Diep C B, Meling G I, Ostrowski J, Trzeciak L, Guzinska-Ustymowicz K, Zalewski B, Capellá G M, Moreno V, Peinado M A, Lönnroth C, Lundholm K, Sun X F, Jansson A, Bouzourene H, Hsieh L-L, Tang R, Smith D R, Allen-Mersh T G, Khan Z A J, Shorthouse A J, Silverman M L, Kato S, Ishioka C
Abstract excerpt
BACKGROUND: Loss of TP53 function through gene mutation is a critical event in the development and progression of many tumour types including colorectal cancer (CRC). In vitro studies have found considerable heterogeneity amongst different TP53 mutants in terms of their transactivating abilities. The aim of this work was to evaluate whether TP53 mutations classified as functionally inactive (< or=20% of wildtype...
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