Article
[Analysis of point mutations in BRCA1 gene using hybridization on hydrogel microchips].
Molekuliarnaia biologiia - 1 Jan 2000
Fedorova O E, Sinitska O N, Tikhomirova L P, Vishnevskaia Ia V, Zasedatelev A S, Nasedkina T V
Abstract excerpt
Germ-line mutations in BRCA1 gene account for a substantial proportion of inherited breast and ovarian cancers. Identification of these mutations allows molecular diagnosis for breast cancer susceptibility. We have developed method for identification of 185delAG, 300T>G, 4153delA, 4158A>G and 5382insC mutations in BRCA1 gene using hybridization with microarray of geL-immobilized oligonucleotides (microchip). The...
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