Article
[Infrared fluorescent markers for microarray DNA analysis on biological microchip].
Molekuliarnaia biologiia - 1 Jan 2000
Spitsyn M A, Shershov V E, Kuznetsova V E, Barsky V E, Egorov E E, Emelyanova M A, Kreindlin E Ya, Lysov Yu P, Guseinov T O, Fesenko D E, Lapa S A, Surzhikov S A, Abramov I S, Nasedkina T V, Zasedatelev A S, Chudinov A V
Abstract excerpt
To expand the informational capabilities of molecular genetic research, on the biological microchips, new indotricarbocyanine dyes that fluoresce in the near infrared (IR) spectral region have been synthesized. The developed IR dyes were studied using a biochip-based test system for detection of mutations in the BRCA1/BRCA2 and CHECK2 genes associated with breast cancer. The fluorescent label was introduced to...
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