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Horizontal Transfer of a Virulence Operon to the Ancestor of Mycobacterium tuberculosis

6 Mar 2006

Abstract excerpt

The contribution of interspecies horizontal gene transfer (HGT) to the evolution and virulence of Mycobacterium tuberculosis, the agent of tuberculosis in humans, has been barely investigated. Here we have studied the evolutionary history of the M. tuberculosis Rv0986-8 virulence operon recently identified, through functional genomics approaches, as playing an important role in parasitism of host phagocytic...

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PMID: 16520338
DOI: 10.1093/molbev/msj120

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