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Article

Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C.

The Journal of infectious diseases - 1 Apr 2006

Morishima Chihiro, Polyak Stephen J, Ray Ranjit, Doherty Michael C, Di Bisceglie Adrian M, Malet Peter F, Bonkovsky Herbert L, Sullivan Daniel G, Gretch David R, Rothman Alan L, Koziel Margaret James, Lindsay Karen L

Abstract excerpt

Pretreatment hepatitis C virus (HCV)-specific lymphoproliferative (LP) responses, neutralizing antibody (NA) responses, intrahepatic cytotoxic T lymphocyte (CTL) responses, and HCV quasi-species (QS) diversity and complexity were examined in patients with advanced hepatic fibrosis (Ishak fibrosis score of > or = 3) and prior nonresponse to interferon (IFN)- alpha therapy who were enrolled in the initial phase of...

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Identifiers

PMID: 16518754
DOI: 10.1086/500952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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