Article
T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C.
Hepatology (Baltimore, Md.) - 1 Jun 2005
Kaplan David E, Sugimoto Kazushi, Ikeda Fusao, Stadanlick Jason, Valiga Mary, Shetty Kirti, Reddy K Rajender, Chang Kyong-Mi
Abstract excerpt
Viral genotype and host ethnicity are important predictors of viral clearance during antiviral therapy for chronic hepatitis C virus (HCV) infection. Based on the role of T cells in natural HCV clearance, we hypothesized that T cells may contribute to the genotypic and ethnic difference in treatment outcome. To test this hypothesis, T-cell response to HCV antigens (core, nonstructural NS3/4 and NS5) and control...
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