Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy

2 Mar 2006

Abstract excerpt

BACKGROUND: Multicellular spheroids, an appropriate in vitro system for simulating 3-D tumor micro-milieu can be used for evaluating and predicting tumor response to therapeutic agents including metabolic inhibitors. However, detailed understanding of the nature, distribution and sensitivity/responses of cellular sub-populations to potential therapeutic agents/strategies is required for using this unique model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Glioma Diagnosis and Treatment
Share to Mathematical Biology Tumor Growth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16509995
DOI: 10.1186/1479-5876-4-12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapyPMID 16509995Read ↗

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroidsSemantic proximity Read ↗

The development of necrosis and apoptosis in glioma: experimental findings using spheroid culture systems.Semantic proximity Read ↗

Development of a 3D Tumor Spheroid Model from the Patient’s Glioblastoma Cells and Its Study by Metabolic Fluorescence Lifetime ImagingSemantic proximity Read ↗

High Content Screening Characterization of Head and Neck Squamous Cell Carcinoma Multicellular Tumor Spheroid Cultures Generated in 384-Well Ultra-Low Attachment Plates to Screen for Better Cancer Drug LeadsSemantic proximity Read ↗

Emergent Properties of Tumor Microenvironment in a Real-Life Model of Multicell Tumor SpheroidsSemantic proximity Read ↗

Protocol for Seahorse 3D Mito Stress assay in patient-derived pediatric brain tumor single neurospheresSemantic proximity Read ↗

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugsSemantic proximity Read ↗

A Systematic Comparison Identifies an ATP‐Based Viability Assay as Most Suitable Read‐Out for Drug Screening in Glioma Stem‐Like CellsSemantic proximity Read ↗

Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell NeurospheresSemantic proximity Read ↗

Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a discovery tool.Semantic proximity Read ↗

Towards optimized breast cancer 3D spheroid mono- and co-culture models for pharmacological research and screeningSemantic proximity Read ↗

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant MetabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.