Article
High mutation rates have driven extensive structural polymorphism among human Y chromosomes.
Nature genetics - 1 Apr 2006
Repping Sjoerd, van Daalen Saskia K M, Brown Laura G, Korver Cindy M, Lange Julian, Marszalek Janet D, Pyntikova Tatyana, van der Veen Fulco, Skaletsky Helen, Page David C, Rozen Steve
Abstract excerpt
Although much structural polymorphism in the human genome has been catalogued, the kinetics of underlying change remain largely unexplored. Because human Y chromosomes are clonally inherited, it has been possible to capture their detailed relationships in a robust, worldwide genealogical tree. Examination of structural variation across this tree opens avenues for investigating rates of underlying mutations. We...
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