Article
Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.
Nature genetics - 1 Jun 2016
Poznik G David, Xue Yali, Mendez Fernando L, Willems Thomas F, Massaia Andrea, Wilson Sayres Melissa A, Ayub Qasim, McCarthy Shane A, Narechania Apurva, Kashin Seva, Chen Yuan, Banerjee Ruby, Rodriguez-Flores Juan L, Cerezo Maria, Shao Haojing, Gymrek Melissa, Malhotra Ankit, Louzada Sandra, Desalle Rob, Ritchie Graham R S, Cerveira Eliza, Fitzgerald Tomas W, Garrison Erik, Marcketta Anthony, Mittelman David, Romanovitch Mallory, Zhang Chengsheng, Zheng-Bradley Xiangqun, Abecasis Gonçalo R, McCarroll Steven A, Flicek Paul, Underhill Peter A, Coin Lachlan, Zerbino Daniel R, Yang Fengtang, Lee Charles, Clarke Laura, Auton Adam, Erlich Yaniv, Handsaker Robert E, Bustamante Carlos D, Tyler-Smith Chris
Abstract excerpt
We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26 worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 variants, including single-nucleotide variants, multiple-nucleotide variants, insertions and deletions, short tandem repeats, and copy number variants. Of these, copy number variants contribute the greatest predicted functional impact. We constructed a...
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