Article
Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene.
World journal of gastroenterology - 28 Jan 2006
García-Martin Elena, Mendoza Juan L, Martínez Carmen, Taxonera Carlos, Urcelay Elena, Ladero José M, de la Concha Emilio G, Díaz-Rubio Manuel, Agúndez José A G
Abstract excerpt
AIM: To analyse the role of two common polymorphisms in genes coding for histamine metabolising enzymes as it relates to the risk to develop ulcerative colitis (UC) and the clinical course of these patients. METHODS: A cohort of 229 unrelated patients with UC recruited from a single centre and 261 healthy volunteers were analysed for the presence of Thr105Ile and His645Asp amino acid substitutions at histamine...
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