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Article

Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men.

International journal of andrology - 1 Jun 2006

Harris T P, Gomas K P, Weir F, Holyoake A J, McHugh P, Wu M, Sin Y, Sin I L, Sin F Y T

Abstract excerpt

CAG trinucleotide repeat length in the nuclear polymerase gamma gene (POLgamma) has been shown to be associated with men with reduced fertility. The present study investigated the frequency of CAG repeat length genotypes and three exonuclease motifs of the POLgamma in relation to the frequency of mitochondrial nucleotide substitutions. DNA from semen samples of 93 normozoospermic men and 192 non-normozoospermic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16487403
DOI: 10.1111/j.1365-2605.2005.00633.x

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