Article
Frequent polymorphism of the mitochondrial DNA polymerase gamma gene (POLG) in patients with normal spermiograms and unexplained subfertility.
Human reproduction (Oxford, England) - 1 Jan 2004
Jensen Martin, Leffers Henrik, Petersen Jørgen H, Nyboe Andersen Anders, Jørgensen Niels, Carlsen Elisabeth, Jensen Tina Kold, Skakkebaek Niels E, Rajpert-De Meyts Ewa
Abstract excerpt
BACKGROUND: Male fertility largely depends on the quality of sperm production, which may be affected by environmental and genetic factors. In this study, we explored a possible role of the polymerase gamma (POLG) gene polymorphism, recently reported to be associated with male infertility in some populations. METHODS: The polymorphic CAG repeat (usually 10 codons long) in the POLG gene was studied in 1298 male...
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