Article
DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation.
Cell - 10 Feb 2006
Gehring Mary, Huh Jin Hoe, Hsieh Tzung-Fu, Penterman Jon, Choi Yeonhee, Harada John J, Goldberg Robert B, Fischer Robert L
Abstract excerpt
MEDEA (MEA) is an Arabidopsis Polycomb group gene that is imprinted in the endosperm. The maternal allele is expressed and the paternal allele is silent. MEA is controlled by DEMETER (DME), a DNA glycosylase required to activate MEA expression, and METHYLTRANSFERASE I (MET1), which maintains CG methylation at the MEA locus. Here we show that DME is responsible for endosperm maternal-allele-specific...
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