Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The functional HERG variant 897T is associated with Conn's adenoma.

Journal of hypertension - 1 Mar 2006

Sarzani Riccardo, Pietrucci Francesca, Corinaldesi Christian, Francioni Matteo, Letizia Claudio, D'Erasmo Emilio, Dessì-Fulgheri Paolo, Rappelli Alessandro

Abstract excerpt

OBJECTIVE: Aldosterone secreting adenomas (aldosteronomas) have an unknown molecular origin. Ion channel currents are involved in signal transduction leading to aldosterone synthesis and secretion. HERG (human-ether-a-go-go-related gene) encodes for a potassium channel responsible for the outward rectifying delayed current and it is mutation prone. When mutated it causes most of the familial forms of both long QT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenocortical Adenoma
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrocardiography

Share to Ether-A-Go-Go Potassium Channels

Share to Gene Expression

Share to Hyperaldosteronism

Share to Hypertension

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 16467651
DOI: 10.1097/01.hjh.0000209984.28735.fd

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The functional HERG variant 897T is associated with Conn's adenoma.PMID 16467651Read ↗

[Update on endocrine hypertension].Semantic proximity Read ↗

A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization.Semantic proximity Read ↗

Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas.Semantic proximity Read ↗

A Novel KCNJ5-insT149 Somatic Mutation Close to, but Outside, the Selectivity Filter Causes Resistant Hypertension by Loss of Selectivity for PotassiumSemantic proximity Read ↗

Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG)Semantic proximity Read ↗

Role for germline mutations and a rare coding single nucleotide polymorphism within the KCNJ5 potassium channel in a large cohort of sporadic cases of primary aldosteronism.Semantic proximity Read ↗

Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5.Semantic proximity Read ↗

A Novel Point Mutation in the KCNJ5 Gene Causing Primary Hyperaldosteronism and Early-Onset Autosomal Dominant HypertensionSemantic proximity Read ↗

Role of KCNJ5 in familial and sporadic primary aldosteronism.Semantic proximity Read ↗

Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension.Semantic proximity Read ↗

A Novel Y152C KCNJ5 Mutation Responsible for Familial Hyperaldosteronism Type IIISemantic proximity Read ↗

Missense mutation in the pore region of HERG causes familial long QT syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.