Article
Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2006
Dressman Holly K, Hans Christopher, Bild Andrea, Olson John A, Rosen Eric, Marcom P Kelly, Liotcheva Vlayka B, Jones Ellen L, Vujaskovic Zeljko, Marks Jeffrey, Dewhirst Mark W, West Mike, Nevins Joseph R, Blackwell Kimberly
Abstract excerpt
PURPOSE: Breast cancer is a heterogeneous disease, and markers for disease subtypes and therapy response remain poorly defined. For that reason, we employed a prospective neoadjuvant study in locally advanced breast cancer to identify molecular signatures of gene expression correlating with known prognostic clinical phenotypes, such as inflammatory breast cancer or the presence of hypoxia. In addition, we defined...
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