Article
A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2006
Solberg Leah C, Valdar William, Gauguier Dominique, Nunez Graciela, Taylor Amy, Burnett Stephanie, Arboledas-Hita Carmen, Hernandez-Pliego Polinka, Davidson Stuart, Burns Peter, Bhattacharya Shoumo, Hough Tertius, Higgs Douglas, Klenerman Paul, Cookson William O, Zhang Youming, Deacon Robert M, Rawlins J Nicholas P, Mott Richard, Flint Jonathan
Abstract excerpt
Whole-genome genetic association studies in outbred mouse populations represent a novel approach to identifying the molecular basis of naturally occurring genetic variants, the major source of quantitative variation between inbred strains of mice. Measuring multiple phenotypes in parallel on each mouse would make the approach cost effective, but protocols for phenotyping on a large enough scale have not been...
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