Identification of 3-Hydroxykynurenine Bound to Proteins in the Human Lens. A Possible Role in Age-Related Nuclear Cataract

Abstract excerpt

Age-related nuclear (ARN) cataract is a major cause of world blindness. With the onset of ARN cataract, the normally transparent and colorless lens becomes opaque and can take on colors ranging from orange, brown, and even black. The molecular basis for this remarkable transformation is unknown. ARN cataract is also characterized by extensive oxidation, insolubilization, and cross-linking of polypeptides,...

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