Transparency and non-refractive functions of crystallins--a proposal.

Abstract excerpt

Based on the premise that all crystallins have cellular and metabolically relevant catalytic activities, we propose that aberrant changes in non-crystallin (non-refractive) functions presage the appearance of cataractous pathologies in an otherwise highly stable edifice of transparency. This proposal is based on accumulating evidence from developmental, molecular and genetic studies that have established that...

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