Derivation of Distal Lung Epithelial Progenitors from Murine Embryonic Stem Cells Using a Novel Three‐Step Differentiation Protocol

Abstract excerpt

Embryonic stem cells (ESCs) are a potential source for the cell-based therapy of a wide variety of lung diseases for which the only current treatment is transplantation. However, distal lung epithelium, like many other endodermally derived somatic cell lineages, is proving difficult to obtain from both murine and human ESCs. We have previously obtained alveolar epithelium from ESCs, although final cell yield...

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