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Article

Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium.

BMC genetics - 30 Dec 2005

Duggal Priya, Gillanders Elizabeth M, Mathias Rasika A, Ibay Grace P, Klein Alison P, Baffoe-Bonnie Agnes B, Ou Liang, Dusenberry Ian P, Tsai Ya-Yu, Chines Peter S, Doan Betty Q, Bailey-Wilson Joan E

Abstract excerpt

We compared seven different tagging single-nucleotide polymorphism (SNP) programs in 10 regions with varied amounts of linkage disequilibrium (LD) and physical distance. We used the Collaborative Studies on the Genetics of Alcoholism dataset, part of the Genetic Analysis Workshop 14. We show that in regions with moderate to strong LD these programs are relatively consistent, despite different parameters and...

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PMID: 16451687
DOI: 10.1186/1471-2156-6-S1-S73
PMCID: PMC1866708

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