Article
Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures.
BMC genetics - 30 Dec 2005
Dunn Gerald, Hinrichs Anthony L, Bertelsen Sarah, Jin Carol H, Kauwe John S K, Suarez Brian K, Bierut Laura J
Abstract excerpt
BACKGROUND: Genetic maps based on single-nucleotide polymorphisms (SNP) are increasingly being used as an alternative to microsatellite maps. This study compares linkage results for both types of maps for a neurophysiology phenotype and for an alcohol dependence phenotype. Our analysis used two SNP maps on the Illumina and Affymetrix platforms. We also considered the effect of high linkage disequilibrium (LD) in...
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