Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Minimal Model: Perspective from 2005

1 Jan 2005

Abstract excerpt

The minimal model was proposed over 25 years ago. Despite (or because of) its simplicity it continues to be used today - both as a clinical tool and an approach to understanding the composite effects of insulin secretion and insulin sensitivity on glucose tolerance and risk for type 2 diabetes mellitus. The original assumptions of the model have led to an understanding of the kinetics of insulin in vivo, as well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Metabolism, Diabetes, and Cancer
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16439839
DOI: 10.1159/000089312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Minimal Model: Perspective from 2005PMID 16439839Read ↗

Type 2 Diabetes: One Disease, Many PathwaysSemantic proximity Read ↗

Toward an integrated phenotype in pre-NIDDM.Semantic proximity Read ↗

Revisiting multiple models of progression of β-cell loss of function in type 1 diabetes: Significance for prevention and cure.Semantic proximity Read ↗

Type 2 diabetes mellitus: a disease of the governance of the glucose-insulin system: an experimental metabolic control analysis study.Semantic proximity Read ↗

Pathophysiologic phenotypes of Japanese subjects with varying degrees of glucose tolerance: using the combination of C-peptide secretion rate and minimal model analysis.Semantic proximity Read ↗

Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin.Semantic proximity Read ↗

Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) ModelSemantic proximity Read ↗

A four-stage model explaining the higher risk of Type 2 diabetes mellitus in South Asians compared with European populations.Semantic proximity Read ↗

Hypothesis: muscle insulin resistance is the ("not-so") thrifty genotypeSemantic proximity Read ↗

Metabolic Phenotype of Stage 1 and Stage 2 Type 1 Diabetes Using Modeling of β Cell Function.Semantic proximity Read ↗

Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study.Semantic proximity Read ↗

A multi-scale digital twin for adiposity-driven insulin resistance in humans: diet and drug effectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.