Article
The genetics of malignant melanomas.
Annals of plastic surgery - 1 Jan 1992
Kousseff B G
Abstract excerpt
A review of the hereditary aspects of the malignant melanomas showed causal heterogeneity and similar pathogenesis based on the dysregulation of the paracrine/autocrine growth mechanisms. The genetically different malignant melanomas have a range of recurrence risks from 1% for the nonfamilial, solitary, malignant melanoma to a risk exceeding 70% for the syndromic melanomas of neurocutaneous melanosis and the...
Topics
- Cytogenetics
- Genes, Dominant
- Genetic Counseling
- Growth Substances
- Humans
- Melanocytes
- Melanoma
- Neoplasm Recurrence, Local
- Phenotype
- Prevalence
- Risk Factors
- Skin Neoplasms